Selection of Antimicrobial Agent & effective chemotherapy
In addition to knowledge about the properties of the available antimicrobial agents important considerations in the choice of effective chemotherapy are:
I. The nature and site of the infection.
2. Adverse effects.
3. Factors determining the resistance of organisms to antimicrobial agents.
1. Selection of Antimicrobial Agent in Relationship to the Nature and Site of the Infection
In instances where the nature of the infection can be reliably predicted from the clinical features of the illness, treatment can proceed without isolation of the causative organism. For example, acute follicular tonsillitis and lobar pneumonia are sufficiently characteristic on clinical examination to allow the causative organism and its antibiotic sensitivity to be assumed with a high degree of probability and the appropriate antibiotic (penicillin) given. In acute exacerbations of chronic bronchitis the causative organisms are almost always pneumococci and Haemophilus influenzae and the use of ampicillin or co-trimoxazole is indicated without specific laboratory diagnosis. Read the rest of this entry »